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<div>'''タンパク質分解'''(タンパクしつぶんかい、Proteolysis)は、[[プロテアーゼ]](タンパク質分解酵素)によって行われる[[タンパク質]]の分解([[消化]])である。<br />
<br />
== 用途 ==<br />
タンパク質分解は以下のいくつかの操作に用いられる。<br />
* [[翻訳 (生物学)|翻訳]]後の[[N末端]][[メチオニン]]残基の除去。<br />
* [[細胞膜]]を輸送透過後の[[シグナルペプチド]]の除去。<br />
* [[mRNA]]から翻訳された[[ウイルス]]タンパク質の分離。<br />
* [[アミノ酸]]の源となる食品のタンパク質消化。<br />
* タンパク質の前駆体(プロ酵素、酵素前駆体、前ホルモン)の最終形態への転換。<br />
* 異なった[[細胞周期]]の段階の[[サイクリン]]の分解。<br />
<br />
== 毒性 ==<br />
[[毒蛇]]の[[毒]]もまたタンパク質分解が使われている。この毒は、毒蛇の体外に出ることによって消化液に変化する。タンパク質分解毒は広範囲にわたる毒性作用を引き起こす<ref>Hayes WK. 2005. [http://www.llu.edu/llu/grad/natsci/hayes/research-c-venom.html?PHPSESSID=55842bf3eeb83dcdfec66c45b91925fc Research on Biological Roles and Variation of Snake Venoms.] Loma Linda University.</ref>。<br />
* [[細胞障害性]] (細胞の破壊)<br />
* [[ヘモトキシン]] (血液の破壊)<br />
* [[ミオトキシン]] (筋肉の破壊)<br />
* [[出血]]<br />
<br />
== 関連項目 ==<br />
* [[プロテアソーム]]<br />
<br />
== 脚注 ==<br />
{{脚注ヘルプ}}<br />
<references/><br />
==外部リンク==<br />
*{{脳科学辞典|プロテアソーム}}<br />
<br />
{{一次構造}}<br />
{{biosci-stub}}<br />
{{Chem-stub}}<br />
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{{DEFAULTSORT:へふしとけつこう}}<br />
[[Category:生化学]]<br />
[[Category:タンパク質]]</div>240F:2:5868:1:1454:891E:DC5:2304 Warning: Cannot modify header information - headers already sent by (output started at /home/users/1/sub.jp-asate/web/wiki/extensions/HeadScript/HeadScript.php:3) in /home/users/1/sub.jp-asate/web/wiki/includes/WebResponse.php on line 46